Frank M Longo Selected Research

Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)

1/2022	Post-Stroke Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Attenuates Chronic Changes in Brain Metabolism, Increases Neurotransmitter Levels, and Improves Recovery.
1/2021	Small molecule modulation of the p75 neurotrophin receptor suppresses age- and genotype-associated neurodegeneration in HIV gp120 transgenic mice.
1/2021	Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury.
1/2020	Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.
1/2019	Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.
11/2016	A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
1/2014	A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.
1/2014	Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.
8/2013	Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
8/2009	The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

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Frank M Longo Research Topics

Disease

18	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 12/2002
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 08/2002
6	Huntington Disease (Huntington's Disease) 01/2021 - 08/2008
5	Stroke (Strokes) 01/2022 - 07/2012
5	Cognitive Dysfunction 01/2020 - 12/2002
4	Inflammation (Inflammations) 01/2021 - 11/2013
3	Atrophy 01/2022 - 01/2014
3	Rett Syndrome (Rett's Disorder) 11/2020 - 02/2012
3	Neuroinflammatory Diseases 10/2019 - 07/2012
3	Disease Progression 01/2018 - 01/2014
3	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2018 - 05/2010
3	Neoplasms (Cancer) 12/2014 - 07/2008
3	Wounds and Injuries (Trauma) 12/2014 - 10/2002
3	Spinal Cord Injuries (Spinal Cord Injury) 01/2013 - 02/2008
2	Seizures (Absence Seizure) 01/2022 - 02/2012
2	Epilepsy (Aura) 01/2022 - 01/2018
2	Infarction (Infarctions) 01/2022 - 01/2018
2	Ischemia 01/2021 - 01/2018
2	Neurodevelopmental Disorders 11/2020 - 01/2017
2	Hyperalgesia 01/2019 - 08/2013
2	Ischemic Stroke 01/2018 - 07/2012
2	Mental Disorders (Mental Disorder) 01/2018 - 03/2016
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2022
1	Erectile Dysfunction 01/2021
1	Prostatic Neoplasms (Prostate Cancer) 01/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Tauopathies 01/2020
1	Parkinson Disease (Parkinson's Disease) 01/2020
1	Brain Neoplasms (Brain Tumor) 10/2019
1	Diarrhea 01/2019
1	Blindness (Hysterical Blindness) 01/2019
1	Hyperplasia 01/2019
1	Neuralgia (Stump Neuralgia) 01/2019
1	Chemotherapy-Related Cognitive Impairment 01/2019
1	Herpes Zoster 01/2019
1	Mixed Dementias 01/2018
1	Post-Traumatic Epilepsy (Epilepsy, Post Traumatic) 01/2018
1	Binge Drinking 01/2016
1	Alcoholism (Alcohol Abuse) 01/2016
1	Cicatrix (Scar) 01/2015
1	Peripheral Nervous System Diseases (PNS Diseases) 12/2014
1	Contusions 01/2013
1	Pain (Aches) 01/2013
1	Gliosis 07/2012
1	Tachypnea 02/2012
1	Apnea 02/2012
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2009

Drug/Important Bio-Agent (IBA)

13	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 01/2022 - 10/2002
11	LigandsIBA 01/2021 - 12/2007
10	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022 - 12/2007
10	LM11A-31IBA 01/2022 - 01/2013
6	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 01/2022 - 08/2002
5	Nerve Growth Factors (Neurotrophins)IBA 01/2021 - 01/2003
5	Pharmaceutical PreparationsIBA 01/2016 - 07/2008
4	Cholinergic Agents (Cholinergics)IBA 01/2022 - 04/2005
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 02/2015
4	Phosphotransferases (Kinase)IBA 11/2020 - 07/2012
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 12/2007
3	CytokinesIBA 01/2022 - 01/2019
3	Retinaldehyde (Retinal)IBA 01/2021 - 06/2006
3	TropomyosinIBA 11/2020 - 07/2012
3	Nerve Growth Factor (NGF)IBA 01/2019 - 12/2007
2	N,N',N'- tris(2- hydroxyethyl)- 1,3,5- benzenetricarboxamideIBA 01/2022 - 07/2012
2	trkB ReceptorIBA 01/2022 - 11/2020
2	Therapeutic UsesIBA 01/2021 - 08/2013
2	Methyl-CpG-Binding Protein 2IBA 11/2020 - 02/2012
2	Amyloid (Amyloid Fibrils)IBA 01/2020 - 01/2018
2	Methotrexate (Mexate)FDA LinkGeneric 01/2019 - 07/2008
2	ParvalbuminsIBA 01/2018 - 11/2013
2	Cisplatin (Platino)FDA LinkGeneric 12/2014 - 07/2008
2	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 12/2014 - 01/2009
2	Peptides (Polypeptides)IBA 10/2011 - 06/2006
2	Amyloid beta-PeptidesIBA 08/2009 - 01/2004
2	Neuroprotective AgentsIBA 07/2008 - 01/2004
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2022
1	Phosphodiesterase 5 InhibitorsIBA 01/2021
1	SynucleinsIBA 01/2020
1	Serotonin (5 Hydroxytryptamine)IBA 01/2019
1	Tight Junction ProteinsIBA 01/2019
1	Macrophage Colony-Stimulating FactorIBA 01/2019
1	Claudin-5IBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2018
1	Neuregulin-1 (Neuregulin 1)IBA 01/2018
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	Complement System Proteins (Complement)IBA 01/2017
1	Valine (L-Valine)FDA Link 03/2016
1	Methionine (L-Methionine)FDA Link 03/2016
1	Small Interfering RNA (siRNA)IBA 01/2016
1	Oligoclonal BandsIBA 02/2015
1	Chondroitin Sulfate ProteoglycansIBA 01/2015
1	Monomeric GTP-Binding ProteinsIBA 01/2009
1	CCG 1423IBA 01/2009

Therapy/Procedure

4	Oral Administration 01/2022 - 01/2013
3	Therapeutics 01/2022 - 01/2013
1	Prostatectomy (Retropubic Prostatectomy) 01/2021
1	Radiotherapy 10/2019
1	Drug Therapy (Chemotherapy) 01/2019
1	Injections 01/2018
1	Withholding Treatment 12/2014